MicroRNA-30a promotes extracellular matrix degradation in articular cartilageviadownregulation of Sox9
نویسندگان
چکیده
منابع مشابه
MicroRNA-494 promotes apoptosis and extracellular matrix degradation in degenerative human nucleus pulposus cells
PURPOSE This study investigated the expression and function of the microRNA-494 in intervertebral disc degeneration (IDD). RESULTS MicroRNA-494 expression was upregulated during IDD progression; its overexpression increased the expression of ECM catabolic factors such as matrix metalloproteinase and A disintegrin and metalloproteinase with thrombospondin motif in NP cells while decreasing tha...
متن کاملmicroRNA 30A promotes autophagy in response to cancer therapy
microRNAs (miRNAs) are a class of small regulatory RNAs that regulate gene expression at the post-transcriptional level. miRNAs play important roles in the regulation of development, growth, and metastasis of cancer, and in determining the response of tumor cells to anticancer therapy. In recent years, they have also emerged as important regulators of autophagy, a lysosomal-mediated pathway tha...
متن کاملDegradation of Extracellular Matrix Molecules in Interleukin-1 Alpha Treated Bovine Nasal Cartilage
Background: This work aimed to show and compare the degradation time of some of cartilage extracellular matrix components using an in vitro model for cartilage degradation induced by interleukin-1 alpha. It is known that elucidation of molecular events under Interleukin-1 alpha induction of bovine nasal cartilage could obtain useful data to understand more about involving mechanisms for tissue ...
متن کاملRestoration of the extracellular matrix in human osteoarthritic articular cartilage by overexpression of the transcription factor SOX9.
OBJECTIVE Human osteoarthritis (OA) is characterized by a pathologic shift in articular cartilage homeostasis toward the progressive loss of extracellular matrix (ECM). The purpose of this study was to investigate the ability of rAAV-mediated SOX9 overexpression to restore major ECM components in human OA articular cartilage. METHODS We monitored the synthesis and content of proteoglycans and...
متن کاملExtracellular matrix of ostrich articular cartilage.
The composition and organization of the extracellular matrix of ostrich articular cartilage was investigated, using samples from the proximal and distal surfaces of the tarsometatarsus. For morphological analysis, sections were stained with toluidine blue and analyzed by polarized light microscopy. For biochemical analysis, extracellular matrix components were extracted with 4 M guanidinium chl...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Proliferation
سال: 2016
ISSN: 0960-7722
DOI: 10.1111/cpr.12246